Rev Port Ciencias Vet 1984; 79( 470 ):117 -126. Zhang W, Leonard T, Bath-Hextall F, et al. Chinese organic medication for atopic eczema. Cochrane Database Syst Rev 2004; 4: CD002291. [WITHDRAWED] tribestan tribulus terrestris .
The main goals were to compare the efficacy of extracts of the plant Tribulus terrestris (TT; marketed as Tribestan), in comparison with placebo, for the treatment of men with impotence (ED) and with or without hypoactive sexual desire disorder (HSDD), as well as to keep an eye on the security profile of the drug.
Phase IV, potential, randomized, double-blind, placebo-controlled clinical trial in parallel groups. This research study included 180 males aged in between 18 and 65 years with moderate or moderate ED and with or without HSDD: 90 were randomized to TT and 90 to placebo. Clients with ED and hypertension, diabetes mellitus, and metabolic syndrome were consisted of in the research study.
Each Tribestan film-coated tablet consists of the active substance Tribulus terrestris, herba extractum siccum (35-45:1) 250mg which is standardized to furostanol saponins (not less than 112. 5mg). Each patient received orally 32 film-coated tablets daily after meals, during the 12-week treatment period. At the end of every month, individuals' sexual function, consisting of ED, was assessed by International Index of Erectile Function (IIEF) Questionnaire and Worldwide Efficacy Concern (GEQ).
The main outcome procedure was the change in IIEF score after 12 weeks of treatment. Total randomization (random sorting using optimum allowable% variance) with an equivalent variety of clients in each series was used. This randomization algorithm has the constraint that unequal treatment allotment is not enabled; that is, all groups need to have the exact same target sample size.
All result assessors were also blinded to group allocation. 86 clients in each group finished the study. The IIEF rating improved significantly in the TT group compared with the placebo group (
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